Table 3. Top ten significantly enriched Reactome pathways with C1orf24 and correlated genes from GSE57691 and GSE7084 using Enrichr (https://amp.pharm.mssm.edu/Enrichr/).

Term	Overlap	P-value	Odds ratio	Combined score	Genes
Elastic fiber formation	3/41	4.32E-04	20.32520325	157.4485645	MFAP4; EFEMP1; LOXL4
Extracellular matrix organization	6/283	5.44E-04	5.889281508	44.26820723	MFAP4; EFEMP1; ITGA1; LOXL4; COL8A1; JAM3
Cell–cell communication	4/131	0.001281745	8.481764207	56.48458548	CLDN12; CTNNA1; CDH13; WASL
Cell–cell junction organization	3/61	0.001386	13.6612	89.90722	CLDN12; CTNNA1; CDH13
RHO GTPases activate ROCKs	2/17	0.001678	32.67974	208.8211	PPP1R12A; MYH10
Semaphorin interactions	3/67	0.001817	12.43781	78.49063	DPYSL3; ITGA1; MYH10
RHO GTPases activate PAKs	2/21	0.002568	26.45503	157.7983	PPP1R12A; MYH10
Cell junction organization	3/86	0.003697	9.689922	54.26647	CLDN12; CTNNA1; CDH13
Molecules associated with elastic fibers	2/30	0.005209	18.51852	97.35994	MFAP4; EFEMP1
Adherens junctions interactions	2/31	0.005555	17.92115	93.06567	CTNNA1; CDH13