Table 2. List of Identified Differential Metabolites between Model Group and Healthy Controls.

No	Metabolitea	FCb (model/control)	VIPc	pd
1	PGF2alpha dimethyl amide	−1.37	1.63	0.0138
2	3′, 5′-Cyclic dGMP	−1.03	1.42	0.042
3	lactic acid	2.84	1.55	0.0036
4	Palmitoylcarnitine	1.04	1.53	0.0243
5	Demissidine	1.48	1.55	0.0383
6	16a-Hydroxydydrogesterone	1.61	1.54	0.0069
7	arachidonic acid	2.21	1.91	0.0028
8	Deoxyuridine monophosphate (dUMP)	1.15	1.79	0.0159
9	oleamide	1.78	1.7	0.0078
10	citric acid	1.85	2.14	0.0174
11	1-hexadecyl-2-acetyl-glycero-3-phosphocholine	−1.25	2.05	0.0162
12	glycerol	1.89	1.65	0.022
13	glycine	1.497	1.64	0.0056
14	hexadecanoic acid	1.518	1.52	0.0101
15	pyruvate	1.832	1.66	0.00123
16	eicosatetraenoic acid	1.18	1.84	0.0239

Notes.

^aMetabolites verified by reference compounds, other were directly obtained from library searching.

^bFold change was calculated from the arithmetic mean values of each group. Fold change with a positive value indicates a relatively higher concentration present in model group while a negative value means a relatively lower concentration as compared to the healthy controls.

^cVariable importance in the projection (VIP) was obtained from PLS-DA with a threshold of 1.0.

^dp value was calculated from student t test.