TABLE 2.
Components in HJD for further analysis after ADME screening.
| No | Component | OB (%) | DL | botanical drug | No | Component | OB (%) | DL | botanical drug | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HJD1 | Quercetin | 46.43 | 0.28 | Huanglian | Jun | HJD58 | Magnograndiolide | 63.71 | 0.19 | Huangbo | Chen |
| HJD2 | Magnograndiolide | 63.71 | 0.19 | Huanglian | Jun | HJD59 | Oleic acid | 33.13 | 0.14 | Huangbo | Chen |
| HJD3 | Palmidin A | 35.36 | 0.65 | Huanglian | Jun | HJD60 | Palmidin A | 35.36 | 0.65 | Huangbo | Chen |
| HJD4 | Corchoroside A_qt | 104.95 | 0.78 | Huanglian | Jun | HJD61 | phellamurin_qt | 56.6 | 0.39 | Huangbo | Chen |
| HJD5 | Obacunone | 43.29 | 0.77 | Huanglian | Jun | HJD62 | Poriferast-5-en-3beta-ol | 36.91 | 0.75 | Huangbo | Chen |
| HJD6 | Palmatine | 64.6 | 0.65 | Huanglian | Jun | HJD63 | Kihadalactone A | 34.21 | 0.82 | Huangbo | Chen |
| HJD7 | Berberine | 36.86 | 0.78 | Huanglian | Jun | HJD64 | Phellavin_qt | 35.86 | 0.44 | Huangbo | Chen |
| HJD8 | Coptisine | 30.67 | 0.86 | Huanglian | Jun | HJD65 | Delta 7-stigmastenol | 37.42 | 0.75 | Huangbo | Chen |
| HJD9 | Fagarine | 72.23 | 0.15 | Huanglian | Jun | HJD66 | Phellopterin | 40.19 | 0.28 | Huangbo | Chen |
| HJD10 | Worenine | 45.83 | 0.87 | Huanglian | Jun | HJD67 | Dehydrotanshinone II A | 43.76 | 0.4 | Huangbo | Chen |
| HJD11 | Berberrubine | 35.74 | 0.73 | Huanglian | Jun | HJD68 | Dihydroniloticin | 36.43 | 0.81 | Huangbo | Chen |
| HJD12 | Epiberberine | 43.09 | 0.78 | Huanglian | Jun | HJD69 | Kihadanin A | 31.6 | 0.7 | Huangbo | Chen |
| HJD13 | (R)-Canadine | 55.37 | 0.77 | Huanglian | Jun | HJD70 | Niloticin | 41.41 | 0.82 | Huangbo | Chen |
| HJD14 | Berlambine | 36.68 | 0.82 | Huanglian | Jun | HJD71 | Chelerythrine | 34.18 | 0.78 | Huangbo | Chen |
| HJD15 | Moupinamide | 86.71 | 0.26 | Huanglian | Jun | HJD72 | Candletoxin A | 31.81 | 0.69 | Huangbo | Chen |
| HJD16 | Ent-Epicatechin | 48.96 | 0.24 | Huangqin | Chen | HJD73 | Hericenone H | 39 | 0.63 | Huangbo | Chen |
| HJD17 | EIC | 41.9 | 0.14 | Huangqin | Chen | HJD74 | Hispidone | 36.18 | 0.83 | Huangbo | Chen |
| HJD18 | Wogonin | 30.68 | 0.23 | Huangqin | Chen | HJD75 | Campesterol | 37.58 | 0.71 | Huangbo | Chen |
| HJD19 | (2 R)-7-hydroxy-5-methoxy-2-phenylchroman-4-one | 55.23 | 0.2 | Huangqin | Chen | HJD76 | Melianone | 40.53 | 0.78 | Huangbo | Chen |
| HJD20 | Beta-sitosterol | 36.91 | 0.75 | Huangqin | Chen | HJD77 | Phellochin | 35.41 | 0.82 | Huangbo | Chen |
| HJD21 | Sitosterol | 36.91 | 0.75 | Huangqin | Chen | HJD78 | Obacunone | 43.29 | 0.77 | Huangbo | Chen |
| HJD22 | Stigmasterol | 43.83 | 0.76 | Huangqin | Chen | HJD79 | Palmatine | 64.6 | 0.65 | Huangbo | Chen |
| HJD23 | Norwogonin | 39.4 | 0.21 | Huangqin | Chen | HJD80 | Fumarine | 59.26 | 0.83 | Huangbo | Chen |
| HJD24 | 5,2′-dihydroxy-6,7,8-trimethoxyflavone | 31.71 | 0.35 | Huangqin | Chen | HJD81 | Isocorypalmine | 35.77 | 0.59 | Huangbo | Chen |
| HJD25 | Coptisine | 30.67 | 0.86 | Huangqin | Chen | HJD82 | Berberine | 36.86 | 0.78 | Huangbo | Chen |
| HJD26 | Supraene | 33.55 | 0.42 | Huangqin | Chen | HJD83 | (S)-Canadine | 53.83 | 0.77 | Huangbo | Chen |
| HJD27 | Acacetin | 34.97 | 0.24 | Huangqin | Chen | HJD84 | Coptisine | 30.67 | 0.86 | Huangbo | Chen |
| HJD28 | Methyl linolelaidate | 41.93 | 0.17 | Huangqin | Chen | HJD85 | N-Methylflindersine | 32.36 | 0.18 | Huangbo | Chen |
| HJD29 | Baicalein | 33.52 | 0.21 | Huangqin | Chen | HJD86 | delta7-dehydrosophoramine | 54.45 | 0.25 | Huangbo | Chen |
| HJD30 | Diop | 43.59 | 0.39 | Huangqin | Chen | HJD87 | Rutaecarpine | 40.3 | 0.6 | Huangbo | Chen |
| HJD31 | Epiberberine | 43.09 | 0.78 | Huangqin | Chen | HJD88 | Skimmianin | 40.14 | 0.2 | Huangbo | Chen |
| HJD32 | 5,7,2,5-Tetrahydroxy-8,6-dimethoxyflavone | 33.82 | 0.45 | Huangqin | Chen | HJD89 | Fagarine | 72.23 | 0.15 | Huangbo | Chen |
| HJD33 | Carthamidin | 41.15 | 0.24 | Huangqin | Chen | HJD90 | Worenine | 45.83 | 0.87 | Huangbo | Chen |
| HJD34 | 2,6,2′,4′-tetrahydroxy-6′-methoxychaleone | 69.04 | 0.22 | Huangqin | Chen | HJD91 | Cavidine | 35.64 | 0.81 | Huangbo | Chen |
| HJD35 | Dihydrobaicalin_qt | 40.04 | 0.21 | Huangqin | Chen | HJD92 | Berberrubine | 35.74 | 0.73 | Huangbo | Chen |
| HJD36 | Eriodyctiol (flavanone) | 41.35 | 0.24 | Huangqin | Chen | HJD93 | Ptelein | 72.44 | 0.15 | Huangbo | Chen |
| HJD37 | Salvigenin | 49.07 | 0.33 | Huangqin | Chen | HJD94 | Thalifendine | 44.41 | 0.73 | Huangbo | Chen |
| HJD38 | 5,2′,6′-trihydroxy-7,8-dimethoxyflavone | 45.05 | 0.33 | Huangqin | Chen | HJD95 | Quercetin | 46.43 | 0.28 | Zhizi | Zuo |
| HJD39 | 5,7,2′,6′-tetrahydroxyflavone | 37.01 | 0.24 | Huangqin | Chen | HJD96 | EIC | 41.9 | 0.14 | Zhizi | Zuo |
| HJD40 | Dihydrooroxylin A | 38.72 | 0.23 | Huangqin | Chen | HJD97 | Beta-sitosterol | 36.91 | 0.75 | Zhizi | Zuo |
| HJD41 | Skullcapflavone II | 69.51 | 0.44 | Huangqin | Chen | HJD98 | Kaempferol | 41.88 | 0.24 | Zhizi | Zuo |
| HJD42 | Oroxylin a | 41.37 | 0.23 | Huangqin | Chen | HJD99 | Stigmasterol | 43.83 | 0.76 | Zhizi | Zuo |
| HJD43 | Panicolin | 76.26 | 0.29 | Huangqin | Chen | HJD100 | Oleic acid | 33.13 | 0.14 | Zhizi | Zuo |
| HJD44 | 5,7,4′-trihydroxy-8-methoxyflavone | 36.56 | 0.27 | Huangqin | Chen | HJD101 | Crocetin | 35.3 | 0.26 | Zhizi | Zuo |
| HJD45 | NEOBAICALEIN | 104.34 | 0.44 | Huangqin | Chen | HJD102 | Mandenol | 42 | 0.19 | Zhizi | Zuo |
| HJD46 | DIHYDROOROXYLIN | 66.06 | 0.23 | Huangqin | Chen | HJD103 | Supraene | 33.55 | 0.42 | Zhizi | Zuo |
| HJD47 | Moslosooflavone | 44.09 | 0.25 | Huangqin | Chen | HJD104 | METHYL LINOLEATE | 41.93 | 0.17 | Zhizi | Zuo |
| HJD48 | 11,13-Eicosadienoic acid, methyl ester | 39.28 | 0.23 | Huangqin | Chen | HJD105 | (4aS,6 aR,6aS,6bR,8 aR,10R,12 aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14 b-tetradecahydropicene-4a-carboxylic acid | 32.03 | 0.76 | Zhizi | Zuo |
| HJD49 | Linolenic acid methyl ester | 46.15 | 0.17 | Huangqin | Chen | HJD106 | Methyl vaccenate | 31.9 | 0.17 | Zhizi | Zuo |
| HJD50 | 5,7,4′-trihydroxy-6-methoxyflavanone | 36.63 | 0.27 | Huangqin | Chen | HJD107 | Ammidin | 34.55 | 0.22 | Zhizi | Zuo |
| HJD51 | 5,7,4′-trihydroxy-8-methoxyflavanone | 74.24 | 0.26 | Huangqin | Chen | HJD108 | Isoimperatorin | 45.46 | 0.23 | Zhizi | Zuo |
| HJD52 | Rivularin | 37.94 | 0.37 | Huangqin | Chen | HJD109 | Exceparl M-OL | 31.9 | 0.16 | Zhizi | Zuo |
| HJD53 | bis [(2 S)-2-ethylhexyl] benzene-1,2-dicarboxylate | 43.59 | 0.35 | Huangqin | Chen | HJD110 | Ethyl oleate (NF) | 32.4 | 0.19 | Zhizi | Zuo |
| HJD54 | 5,8,2′-trihydroxy-7-methoxyflavone | 37.01 | 0.27 | Huangqin | Chen | HJD111 | 5-Hydroxy-7-methoxy-2-(3,4,5-trimethoxyphenyl)chromone | 51.96 | 0.41 | Zhizi | Zuo |
| HJD55 | Quercetin | 46.43 | 0.28 | Huangbo | Chen | HJD112 | 3-Methylkempferol | 60.16 | 0.26 | Zhizi | Zuo |
| HJD56 | Beta-sitosterol | 36.91 | 0.75 | Huangbo | Chen | HJD113 | GBGB | 45.58 | 0.83 | Zhizi | Zuo |
| HJD57 | Stigmasterol | 43.83 | 0.76 | Huangbo | Chen | HJD114 | Sudan III | 84.07 | 0.59 | Zhizi | Zuo |