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Absence of intermittent hypoxia (IH)-induced increase in hypoxia-inducible factor (HIF-1α), NADPH oxidase (NOX4) protein, NOX4 mRNA, and fasting plasma insulin levels in β-cell-specific HIF-1−/− mice exposed to IH30d. A: HIF-1α and NOX4 protein; B: NOX4 mRNA; and C: fasting plasma insulin levels in HIF-1α floxIns1CreERT mice with (β-HIF-1α−/−) and without (control) tamoxifen treatment. Data with means ± SE are shown (n = 4). **P value < 0.01; ns, not significant (P value > 0.05).
