Cellular communication network factor 1 (CCN1) bronchoalveolar lavage fluid (BALF) concentrations are higher in subjects with acute respiratory distress syndrome (ARDS) compared with non-ARDS controls. CCN1 concentrations in BALF collected from mechanically ventilated subjects without ARDS (non-ARDS) and from subjects with ARDS (ARDS). Non-ARDS subjects were comprised of patients with cardiogenic pulmonary edema (CPE; n = 26) and patients without any pulmonary edema (no CPE; n = 19). A: CCN1 concentrations were significantly higher in BALF from ARDS vs. non-ARDS subjects. Shown are the individual values, median, and interquartile range (Mann-Whitney U test). B: CCN1 concentrations were different in BALF from subjects with no cardiogenic pulmonary edema (no CPE), cardiogenic pulmonary edema (CPE), and ARDS. Shown are the individual values, median, and interquartile range (Kruskal-Wallis test). CCN1 was measured by ELISA.