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. Author manuscript; available in PMC: 2021 Jan 7.
Published in final edited form as: Cell Rep. 2020 Jul 28;32(4):107952. doi: 10.1016/j.celrep.2020.107952

Figure 7. A Model of Msi1+ Cells in Maintaining and Regenerating Intestinal Epithelium.

Figure 7.

A subset of Msi1+ ISCs that exhibit DNA-damage resistance are cycling faster than Lgr5high CBCs, and fast repopulation of the intestinal epithelium at early stage when Lgr5high cells are not emerging. Msi1+ cells preferentially produce Paneth cells during homeostasis and upon radiation repair.