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. 2020 Sep 14;319(5):F796–F808. doi: 10.1152/ajprenal.00187.2020

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Fig. 4. — Effect of ischemic time on severity of renal injury and survival in RAR-related orphan receptor C (Rorc)^+/+ vs. Rorc^−/− rats. Rorc^+/+ and Rorc^−/− rats were subjected to either 40 or 50 min bilateral renal ischemia-reperfusion (I/R) and allowed to recover for up to 4 days. A: serum creatinine values are shown at 24 and 48 h following I/R in Rorc ^+/+ and Rorc^−/− rats, respectively. *P < 0.05 Rorc^−/− and Rorc^+/+ rats following 40 min; Rorc^+/+ and Rorc^−/− rats were not different at 50 min of I/R. B: representative hematoxylin-eosin-stained cross sections through renal outer medulla are shown 2 days following renal I/R. Necrotic damage was evident in all samples (arrow) and no statistically significant differences were evident. Magnification is shown. C: Kaplan–Meier survival curve is shown indicating increased mortality beginning 2 days post-I/R in Rorc^−/− rats following 50 min of injury vs. Rorc^−/− rats following 40 min of injury or Rorc^+/+ rats following 40 or 50 min of injury. N = 7–10 per group. Note that the lines defining ^+/+ 40 min I/R, ^+/+ 50 min I/R, and ^−/− 40 min I/R are overlapping at 100%.