Table 4.

Blood chemistry 48 h following ischemia/reperfusion in Rorc^+/+ and Rorc ^−/− rats

	Rorc+/+ Sham	Rorc−/− Sham	Rorc+/+ I/R (50 min)	Rorc−/− I/R (50 min)	Rorc−/− I/R (50 min) IL-17
n	6	5	6	6	5
pH	7.38 ± 0.02	7.37 ± 0.02	7.37 ± 0.02	7.24 ± 0.04*	7.37 ± 0.03†
Na+, mmol/L	139.2 ± 0.5	140.4 ± 1.1	143.3 ± 1.1	137.0 ± 2.3	141.0 ± 0.6
K+, mmol/L	3.7 ± 0.1	3.5 ± 0.1	4.1 ± 0.2	5.0 ± 0.5*	4.3 ± 0.3†
Cl−, mmol/L	108.5 ± 0.8	110.2 ± 1.9	110 ± 0.7	101.5 ± 2.0*	106.0 ± 1.5†
${\text{HCO}}_3^{-}$, mmol/L	27.8 ± 1.0	27.5 ± 1.0	29.5 ± 0.7	21.6 ± 2.7*	24.2 ± 2.8
Base deficit, mmol/L	2.0 ± 1.0	1.4 ± 0.7	3.3 ± 0.7	−6.0 ± 2.9*	2.0 ± 1.3†
Anion gap	6.6 ± 0.5	6.2 ± 0.6	8.9 ± 0.6	18.9 ± 2.5*	15.1 ± 3.7

Values are means ± SE. IL-17 was administered at a dose of 100 ng·kg⁻¹·day⁻¹ by an osmotic minipump. I/R, ischemia-reperfusion. Rorc, RAR-related orphan receptor C.

^*P < 0.05 Rorc^−/− vs. Rorc^+/+;

^†P < 0.05 Rorc^−/− vehicle vs. Rorc^−/− IL-17 treated, by one-way ANOVA and the Student–Newman–Keuls test.