Table 1.
Shared loci between loneliness and SMDs and CVD risk factors.
| Associated phenotype | Shared conjFDR | Loci (n) concordant effect (%) | Genetic correlation |
|---|---|---|---|
| SMD | |||
| MD | 67 | 95.5% | 0.570 (p = 2.74E−116) |
| SCZ | 54 | 74.1% | 0.167 (p = 5.08E–12) |
| BD | 28 | 61.7% | 0.018 (p = 0.60) |
| CVD risk factor | |||
| BMI | 36 | 69.4% | 0.182 (p = 3.73E−17) |
| TC | 6 | 83.3% | 0.039 (p = 0.26) |
| HDL-C | 5 | 60.0% | −0.101 (p = 6.62E−5) |
| SBP | 9 | na | na |
| DBP | 4 | na | na |
| T2D | 1 | na | 0.119 (p = 0.0003) |
| CAD | 12 | 58.3% | 0.129 (p = 4.60E−5) |
| Smoking | 0 | na | 0.252 (p = 0.0002) |
Number of shared loci at conjFDR <0.05, concordant effect directions in percentage, and genetic correlation estimated by LD score regression. Bold values in the genetic correlation column are significant after Bonferroni correction (p < 0.05/11).
SMD severe mental disorder, MD major depression, SCZ schizophrenia, BD bipolar disorder, CVD cardiovascular disease, BMI body mass index, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, SBP systolic blood pressure, DBP diastolic blood pressure, T2D type 2 diabetes mellitus, CAD coronary heart disease, na not available, conjFDR conjunctional FDR, Na effect directions not available from the SBP/DBP GWAS. As there were no shared loci between loneliness and smoking, percentage of concordant effects were not computed. As only one shared locus was found between T2D and loneliness, percentage with concordant effect is not given.