Table 1.
Features of the clinical samples included in this study
| Clinical condition | Sample type | ORF1 RT-qPCR viral load (virus/parasite) | Nested RT-PCR | 18S RT-qPCR | Leishmania RNA virus 1 status | Lesion localization | Leishmania species | Region | |
|---|---|---|---|---|---|---|---|---|---|
| Ito et al.27 | Ramos et al.24 | CT | |||||||
| ML | Isolate | 9,50E+00 | 6,47E+00 | NA | NA | Positive | Nose | L. (V.) braziliensis | Amazon |
| ML | Isolate | 2,24E−04 | 1,09E−01 | NA | NA | Positive | Cheek | L. (V.) braziliensis | Andean |
| ML | Isolate | NA | NA | NA | NA | Negative | Nose | L. (V.) panamensis | Andean |
| ML | Isolate | NA | NA | NA | NA | Negative | Nose | L. (V.) braziliensis | Orinoquía |
| ML | Isolate | 2,97E−03 | 3,84E−03 | NA | NA | Positive | Nose | L. (V.) braziliensis | Andean |
| ML | Isolate | NA | NA | NA | NA | Negative | Nose | L. (V.) braziliensis | Andean |
| CLTF | Isolate | 5,47E+00 | 1,90E+00 | NA | NA | Positive | Face and neck | L. (V.) braziliensis | Amazon |
| CLTF | Isolate | NA | NA | NA | NA | Negative | Legs | L. (V.) braziliensis | Orinoquía |
| CLTF | Isolate | 1,74E−01 | 1,12E+01 | NA | NA | Positive | Upper limbs | L. (V.) braziliensis | Orinoquía |
| CLTF | Isolate | NA | NA | NA | NA | Negative | Upper limbs | L. (V.) braziliensis | Amazon |
| CLTF | Isolate | NA | NA | NA | NA | Negative | Multiple injuries | L. (V.) braziliensis | Orinoquía |
| CLTF | Isolate | NA | NA | NA | NA | Negative | Multiple injuries | L. (V.) braziliensis | Orinoquía |
| CLTF | Isolate | NA | NA | NA | NA | Negative | Upper limbs | L. (V.) braziliensis | Orinoquía |
| CLTF | Isolate | NA | NA | NA | NA | Negative | Upper limbs | L. (V.) braziliensis | Orinoquía |
| CLTF | Isolate | 1,21E+01 | 3,91E+00 | NA | NA | Positive | Upper limbs | L. (V.) braziliensis | Orinoquía |
| CLTF | Isolate | 1,06E−01 | 9,90E−01 | NA | NA | Positive | Multiple injuries | L. (V.) braziliensis | Orinoquía |
| CLTF | Isolate | NA | NA | NA | NA | Negative | Multiple injuries | L. (V.) braziliensis | Amazon |
| CLTF | Isolate | 4,02E+01 | 1,44E+01 | NA | NA | Positive | Upper limbs | L. (V.) braziliensis | Orinoquía |
| CLTF | Isolate | 9,31E+00 | 3,57E+00 | NA | NA | Positive | Upper limbs | L. (V.) braziliensis | Amazon |
| CLTF | Isolate | NA | NA | NA | NA | Negative | Face and neck | L. (V.) braziliensis | Pacific |
| ML | Biopsy | NA | NA | Positive | 32,22 | Positive | Nose | Leishmania spp. | Andean |
| ML | Biopsy | NA | NA | Negative | 34,73 | Negative | Nose | L. (V.) braziliensis | Orinoquía |
| ML | Biopsy | NA | NA | Negative | 34,47 | Negative | Nose | L. (V.) panamensis | Andean |
| ML | Biopsy | NA | NA | Positive | 35,11 | Positive | Nose | L. (V.) braziliensis | Andean |
| ML | Biopsy | NA | NA | Negative | 30,3 | Negative | Nose | Leishmania spp. | Caribbean |
| ML | Biopsy | NA | NA | Negative | 27,72 | Negative | Nose | L. (V.) panamensis | Andean |
| ML | Biopsy | NA | NA | Negative | 32,59 | Negative | Nose | L. (V.) braziliensis | Amazon |
| ML | Biopsy | NA | NA | Negative | 35,64 | Negative | Nose | L. (V.) braziliensis | Orinoquía |
| ML | Biopsy | NA | NA | Negative | 31,45 | Negative | Nose | L. (V.) braziliensis | Orinoquía |
| CLTF | Biopsy | NA | NA | Positive | 32,45 | Positive | Legs | L. (V.) braziliensis | Orinoquía |
| CLTF | Biopsy | NA | NA | Negative | 28,07 | Negative | Upper limbs | L. (V.) braziliensis | Amazon |
| CLTF | Biopsy | NA | NA | Positive | 24,85 | Positive | Multiple injuries | L. (V.) braziliensis | Orinoquía |
| CLTF | Biopsy | NA | NA | Positive | 21,98 | Positive | Multiple injuries | L. (V.) braziliensis | Orinoquía |
| CLTF | Biopsy | NA | NA | Positive | 27,08 | Positive | Upper limbs | L. (V.) braziliensis | Orinoquía |
| CLTF | Biopsy | NA | NA | Negative | 29,59 | Negative | Multiple injuries | L. (V.) braziliensis | Amazon |
| CLTF | Biopsy | NA | NA | Negative | 31,44 | Negative | Face and neck | L. (V.) braziliensis | Pacific |
| Lepromatous leprosy | Biopsy | NA | NA | Negative | Undetermined | Negative | Nose | NA | No data |
| Traumatic piercing | Biopsy | NA | NA | Negative | Undetermined | Negative | Nose | NA | No data |
| Sporotrichosis | Biopsy | NA | NA | Negative | Undetermined | Positive | Nose | NA | No data |
| Acute and chronic reactions secondary to insect bite | Biopsy | NA | NA | Negative | Undetermined | Negative | Nose | NA | No data |
| Deep mycosis | Biopsy | NA | NA | Negative | Undetermined | Negative | Nose | NA | No data |
| Squamous cell carcinoma | Biopsy | NA | NA | Negative | Undetermined | Negative | Nose | NA | No data |
CLTF = cutaneous leishmaniasis with therapeutic failure; L. (V.) braziliensis = Leishmania (Viannia) braziliensis; L. (V.) panamensis = Leishmania (Viannia) panamensis; ML = mucosal Leishamniasis; NA not applicable.