Table 6.

Metabolites and their pathways altered in placentomes with maternal cortisol treatment

Pathway		Mean ± SE
Metabolite	P Value	Control	CORT	Fold Change CORT/Ctrl)
Glutathione metabolism
Glutathione	0.01	0.27 ± 0.02	0.17 ± 0.02	−0.64
Ascorbate	0.02	0.31 ± 0.02	0.25 ± 0.01	−0.30
Glutamate	0.05	1.17 ± 0.06	0.95 ± 0.09	−0.30
Glycerophospholipid metabolism
Ethanolamine	0.04	0.32 ± 0.03	0.21 ± 0.03	−0.65
Cholines (choline/phosphocholine)	0.04	1.09 ± 0.07	0.80 ± 0.12	−0.45

Pathways significantly changed by cortisol treatment had a false discovery rate of 0.003. For individual metabolites, an unadjusted P ≤ 0.05 was considered significant. CORT, cortisol treated.