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. 2020 Dec;63(6):767–779. doi: 10.1165/rcmb.2019-0085OC

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Figure 2. — Proteomic analysis of the apical secretions of CLLO smoke–exposed HTBE cells (n = 6/group). (A1) Venn diagrams show (a) significant differentially expressed proteins shared across groups and unique to each exposure group (air, KCSs, and CLLOs [SSWs and GBKs]) and (A2) quantitative profile analysis of significant proteins across the CLLO groups (SSWs, GBKs, and HTTs). (B) Principal-component (PC) analysis of protein expression reveals clustering of the CLLO- (SSW, GBK, and HTT), KCS-, and air-exposed groups. A hierarchical heatmap displays the clustering of protein expression after KCS- and CLLO-smoke exposure. (C) CLLOs resulted in a clustering pattern different from those found for cigarettes and air. A functional-enrichment pathway analysis of the differentially upregulated proteins after CLLO exposure revealed exposure-induced changes in a number of proteins related to (D) the innate immune pathways (red) and (E) oxidative-stress/oxidative stress–induced cell-death pathways (blue).

Figure 2. — Proteomic analysis of the apical secretions of CLLO smoke–exposed HTBE cells (n = 6/group). (A1) Venn diagrams show (a) significant differentially expressed proteins shared across groups and unique to each exposure group (air, KCSs, and CLLOs [SSWs and GBKs]) and (A2) quantitative profile analysis of significant proteins across the CLLO groups (SSWs, GBKs, and HTTs). (B) Principal-component (PC) analysis of protein expression reveals clustering of the CLLO- (SSW, GBK, and HTT), KCS-, and air-exposed groups. A hierarchical heatmap displays the clustering of protein expression after KCS- and CLLO-smoke exposure. (C) CLLOs resulted in a clustering pattern different from those found for cigarettes and air. A functional-enrichment pathway analysis of the differentially upregulated proteins after CLLO exposure revealed exposure-induced changes in a number of proteins related to (D) the innate immune pathways (red) and (E) oxidative-stress/oxidative stress–induced cell-death pathways (blue).