Figure 5.

In vivo proteomic analysis of BAL fluid (BALF) from mice exposed to CLLO or cigarette smoke daily for 5 days. (A) A hierarchical heatmap displays the clustering of protein expression after exposure to KCSs, CLLOs, or air. The clustering patterns of protein expression after CLLO-smoke exposure differ from those observed after cigarette or air-sham exposure. (B) Venn diagrams show the number of significantly increased proteins in BALF from animals exposed to tobacco-product smoke compared with air. (C) PC analysis of the protein-expression levels in mouse BALF illustrates the clustering of samples after CLLO, cigarette, or air-sham exposure.