Figure 7.

Analysis of chemical compounds. (A) Presence (red) and absence (white) of compounds identified in the particulate phase of smoke from tobacco products by gas chromatography–mass-spectrometry. (B) Stacked chromatograms of trimethylsilyl-derivatized filter extracts collected from mainstream KCS and CLLO smoke. (C) Unique and shared chemical entities were identified in the smoke particles from different CLLO products and KCSs. (D) Time course of the nicotine concentrations in smoke-exposed HTBE-cell apical secretions after exposure to tobacco products. Significant differences were observed in mainstream smoke and *air or ^‡KCSs compared with CLLOs. Data are expressed as the mean ± SEM. *P < 0.05 by two-way ANOVA with repeated measurements and ^‡P < 0.05 by Sidak’s multiple-comparison test.