Table 2.
Meta-analysis results of the three novel IgAN susceptibility loci
| Information | TA | NTA | Study | TAF_A | TAF_U | P | PGC | OR (95% CI) | I2 | PQ |
|---|---|---|---|---|---|---|---|---|---|---|
| rs2240335Chr1:17674537PADI4 | A | C | Chinese Southern | 0.606 | 0.586 | 1.13e−02 | 1.132 (1.028 to 1.245) | |||
| A | C | Chinese Northern | 0.401 | 0.408 | 8.00e−01 | 0.979 (0.867 to 1.203) | ||||
| A | C | Chinese dbGaP | 0.597 | 0.555 | 7.07e−03 | 1.184 (1.047 to 1.340) | ||||
| A | C | Validation Southern | 0.605 | 0.581 | 3.00e−04 | 1.105 (1.047 to 1.167) | ||||
| A | C | Validation Northern | 0.601 | 0.577 | 1.92e−02 | 1.104 (1.016 to 1.199) | ||||
| A | C | Meta_Chinese | 8.10e−08 | 1.09e−07 | 1.109 (1.068 to 1.152) | 0.00 | 4.76e−01 | |||
| A | C | Italian dbGaP | 0.405 | 0.374 | 1.54e−02 | 1.161 (1.029 to 1.311) | ||||
| A | C | Meta-analysis | 5.10e−09 | 7.64e−09 | 1.114 (1.074 to 1.155) | 0.00 | 4.78e−01 | |||
| rs6427389Chr1:157632011FCRL3 | C | A | Chinese Southern | 0.806 | 0.771 | 3.46e−04 | 1.230 (1.098 to 1.377) | |||
| C | A | Chinese Northern | 0.792 | 0.758 | 2.01e−02 | 1.258 (1.037 to 1.527) | ||||
| C | A | Chinese dbGaP | 0.790 | 0.769 | 1.01e−01 | 1.133 (0.727 to 1.315) | ||||
| C | A | Validation Southern | 0.793 | 0.769 | 2.34e−05 | 1.150 (1.078 to 1.227) | ||||
| C | A | Validation Northern | 0.783 | 0.775 | 3.54e−01 | 1.048 (0.950 to 1.156) | ||||
| C | A | Meta_Chinese | 5.39e−09 | 9.83e−09 | 1.144 (1.093 to 1.197) | 28.71 | 2.30e−01 | |||
| C | A | Italian dbGaP | 0.658 | 0.644 | 3.96e−01 | 1.054 (0.840 to 1.071) | ||||
| C | A | Meta-analysis | 8.18e−09 | 1.44e−08 | 1.132 (1.086 to 1.181) | 34.78 | 2.16e−01 | |||
| rs6942325Chr6:249714DUSP22, IRF4 | G | A | Chinese Southern | 0.792 | 0.769 | 1.56e−02 | 1.150 (1.027 to 1.288) | |||
| G | A | Chinese Northern | 0.777 | 0.761 | 5.44e−02 | 1.201 (0.997 to 1.446) | ||||
| G | A | Chinese dbGaP | 0.788 | 0.737 | 1.04e−04 | 1.327 (1.150 to 1.531) | ||||
| G | A | Validation Southern | 0.790 | 0.770 | 5.95e−04 | 1.119 (1.050 to 1.194) | ||||
| G | A | Validation Northern | 0.792 | 0.761 | 3.79e−04 | 1.193 (1.082 to 1.315) | ||||
| G | A | Meta_Chinese | 3.33e−11 | 5.62e−11 | 1.163 (1.112 to 1.216) | 20.83 | 2.82e−01 | |||
| G | A | Italian dbGaP | 0.988 | 0.983 | 1.18e−01 | 1.537 (0.896 to 2.637) | ||||
| G | A | Meta-analysis | 1.62e−11 | 2.80e−11 | 1.165 (1.114 to 1.218) | 2.12 | 3.12e−01 |
TA, test allele; NTA, non–test allele; TAF_A, frequency of TA in patients; TAF_U, frequency of TA in controls; PGC, association P value after adjusting λGC by META software; PQ, P value of heterogeneity test; Chr1, chromosome 1; Chr6, chromosome 6.