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. 2021 Jan 7;16(1):e0245190. doi: 10.1371/journal.pone.0245190

Fig 4. Levels of the tumor inflammatory mediators according the OSCC stage.

Fig 4

TNF-alpha (A), IL-6 (C), IL1-beta (E) and MCP-1 levels (G). ANOVA followed by Tukey multiple comparison demonstrated that the levels of inflammatory mediators were increased in the large tumors from isolated rats. Correlation between levels of the inflammatory mediators and OSCC volume. The Pearson correlation test showed a positive relationship between the tumor levels of TNF-alpha (B), IL-6 (D), IL1-beta (F) and MCP-1 (H) and tumor volume. *p<0.05 indicates a statistically significant difference. *p<0.05 and **p<0.001. Bar graphs represent the mean ± standard error of the mean (SEM).