. 2021 Jan 7;12(1):53. doi: 10.1038/s41419-020-03283-2

Table 1.

The list of genes with most significant change upon IL-38 treatment in the co-cultured respiratory epithelial cells with macrophages.

Cluster significantly up and down-regulated genes
Co-cultured A549 with HMDMs	Down: SNCA, CAMK2B, CLTRN, MAPK15, TRIM34, KCNJ8 Up: IL1R2, CLSTN2, MME, PCDH18, NOTCH4, SLC22A1, CLDN4, MTRNR2L8, PRR4, NDN, CLDN9, CCL15, IGKV2-24, IGKV1-27, IGLV4-69, IGLV2-18, IGHV4-59
Co-cultured BEAS-2B with HMDMs	Down: HBB, COL1A2, COL3A1, CA1, HBA2, FCAMR, IL3, SCUBE3, SFRP4, MAOB, NOX1, SPON1, LUM, DCN, SLC4A1, C17orf99, IGKV1-17, IGLV7-43, IGLV3-1, IGHV3-49, IGLV3-9 Up: CTSK, ADORA1, CHIT1, HAAO, PPBP, SPP1, HIST1H4D, CLEC5A, LPL, GAL, GPR84, RAD51, ATP6V0C, MT1A

Cluster significantly up and down-regulated genes

Co-cultured A549 with HMDMs

Down: SNCA, CAMK2B, CLTRN, MAPK15, TRIM34, KCNJ8

Up: IL1R2, CLSTN2, MME, PCDH18, NOTCH4, SLC22A1, CLDN4, MTRNR2L8, PRR4, NDN, CLDN9, CCL15, IGKV2-24, IGKV1-27, IGLV4-69, IGLV2-18, IGHV4-59

Co-cultured BEAS-2B with HMDMs

Down: HBB, COL1A2, COL3A1, CA1, HBA2, FCAMR, IL3, SCUBE3, SFRP4, MAOB, NOX1, SPON1, LUM, DCN, SLC4A1, C17orf99, IGKV1-17, IGLV7-43, IGLV3-1, IGHV3-49, IGLV3-9

Up: CTSK, ADORA1, CHIT1, HAAO, PPBP, SPP1, HIST1H4D, CLEC5A, LPL, GAL, GPR84, RAD51, ATP6V0C, MT1A