Figure 4.

Enhanced expression of CD39 and CD73 on activated mouse CD4⁺ and CD8⁺ T cells in vivo. Expression of CD39 and CD73 was measured in mice bearing melanoma (ret tu) and PDAC (Panc02) as well as in healthy animals by flow cytometry (n = 9–27). Data are presented as the percentage of CD39⁺ or CD73⁺ cells within CD25⁻FoxP3⁻ naïve and activated CD25⁺FoxP3⁻ subsets of CD4⁺ Tcon (A-D) from tumors (A,B) and spleens (C,D). (E) shows the percentage of CD39⁺ or CD73⁺ cells among naïve CD69⁻ and activated CD69⁺ subsets of CD8⁺ T cells from mice with PDAC (Panc02) and healthy animals. *P < .05, **P < .01, ***P < .001