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. Author manuscript; available in PMC: 2021 Jan 7.
Published in final edited form as: Nat Genet. 2020 May 11;52(6):615–625. doi: 10.1038/s41588-020-0618-1

Extended Data Fig. 6. H3K27me3 and MLL2 dependent transcription.

Extended Data Fig. 6

(a) Heatmaps show the corresponding log2 fold changes in gene expression in 1) MLL2KO vs. WT mESCs, 2) MLL2KOSUZ12KO#1 vs. MLL2KO mESCs, 3) MLL2KOSUZ12KO#2 vs. MLL2KO mESCs, 4) MLL2KOSUZ12KO#3 vs. MLL2KO mESCs and 5) MLL2KOSUZ12KO#4 vs. MLL2KO mESCs. The experiment was repeated two times independently with similar results. (b) ChIP-seq tracks of H3K27me3 occupancy at the Snx24 locus in WT, MLL2KO and MLL2KO 100 nM 5dAza for 4 days treated mESCs. The experiment was repeated two times independently with similar results.