Table 8.

Overall survival analysis by Cox proportional Hazards model^# for 45 osteosarcoma patients

	Univariate			Multivariate
	HR	95% CI		HR	95% CI
PD-L1*
Low vs. high	3.10	1.21	9.19	2.71	1.03	8.19
Grade
3 vs. 2	1.90	0.48	17.3	1.60	0.37	14.9
Gender
Male vs. Female	0.93	0.38	2.53	0.94	0.38	2.60
Age at diagnosis	1.01	0.99	1.03	1.00	0.97	1.02
Size
>9 cm vs. ≤9 cm	2.94	1.11	9.59	2.17	0.81	7.09
Necrosis following preoperative chemotherapy ≤90% vs >90%	9.70	1.33	1234.8	6.79	0.87	875.5

^#Inference under Firth-type bias correction.

Likelihood ratio tests for PD-L1 (univariate p = 0.0173; multivariate p = 0.0192).

*Log2PDL1-dichotomized at the median.