Table 5. Sterol levels in supplemented CF mice in comparison to supplemented WT and no supplemented CF mice.
| Serum | Liver | ||||
|---|---|---|---|---|---|
| Mouse populations | Phytosterols (mg/dL) | Cholesterol (mg/dL) | Lathosterol (ng/mg tissue) | Cholesterol (μg/mg tissue) | Cholestanol (ng/mg tissue) |
| A) WT with cholesterol supplementation | 0.25 (0.08) | 122.1 (8.3) | < 0.2 | 15.1 (4.6) | 36.0 (7.7) |
| p value (A vs B)a | < 0.005 | < 0.05 | < 0.005 | < 0.05 | < 0.005 |
| B) CF with cholesterol supplementation | 0.49 (0.06) | 95.9 (9.0) | 4.4 (1.2) | 3.5 (0.2) | 10.7 (3.1) |
| p value (B vs C)a | < 0.005 | n.s. | n.s. | < 0.05 | n.s. |
| C) CF without supplementation | 0.97 (0.14) | 81.7 (6.3) | 4.7 (0.7) | 2.6 (0.1) | 9.5 (1.1) |
aUnpaired Student t test. n.s.: not significant, p > 0.05. CF: Cystic fibrosis mice; WT: wild type mice.