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. 2020 Dec 31;2020:8861994. doi: 10.1155/2020/8861994

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Copyright © 2020 Yixiao Gu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of inhibitor on mechanical and thermal pain threshold (n = 7/group). KN93 was given on the third day of CFA injection. The paw withdrawal threshold was tested at base, 1 day, 3 days, 5 days, and 7 days. (a) The paw withdrawal frequency of the CFA + KN93 group was increased after KN93 injection (3 days), compared with the CFA + EA group on the ipsilateral side. KN92 has no effect on paw withdrawal frequency. (c) The paw withdrawal latency of the CFA + KN93 group was increased after KN93 injection (3 days), compared with the CFA + EA group on the ipsilateral side. KN92 has no effect on the paw withdrawal latency. (b, d) No difference among the 4 groups on the contralateral side. ^∗P < 0.05, ^∗∗P < 0.01 vs. CFA + EA group.