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. Author manuscript; available in PMC: 2021 Jan 7.
Published in final edited form as: FASEB J. 2020 Jun 15;34(8):10073–10095. doi: 10.1096/fj.202000672R

Fig. 3: Excitatory effects of CCh and neostigmine on ICC-IM are mediated by M3 receptors.

Fig. 3:

A STMs showing the effect of an M2 receptor antagonist, AF-DX 116 (0.1 μM), and an M3 receptor antagonist, DAU 5884 (0.1 μM), on the excitatory effects of CCh (1 μM) on Ca2+ transients in ICC-IM in the presence of TTX (1 μM). B Summary data showing effects of AF-DX 116 and DAU 5884 on Ca2+ transient frequency, amplitude, duration and spatial spread in the presence of CCh and TTX, c=10, n=4. C STMs showing the effects AF-DX 116 (0.1 μM) and DAU 5884 (0.1 μM) on the excitatory effects of neostigmine (3 μM) on Ca2+ transients in ICC-IM. D Summary data showing the effects of AF-DX 116 and DAU 5884 on Ca2+ transient frequency, amplitude, duration and spatial spread in the presence of neostigmine, c=12, n=3.