Fig. 2. CardioBoost outperforms state-of-the-art genome-wide prediction tools on holdout test data.

(a, b) Precision recall curves and receiver operating characteristic (ROC) curves for cardiomyopathy variant pathogenicity prediction. (c, d) Precision recall curves and ROC curves for inherited arrhythmia variant pathogenicity prediction. The dashed lines demonstrate the performance of a random classifier.