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. 2020 Oct 13;40(1):28–45. doi: 10.1038/s41388-020-01498-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A qRT-PCR analysis of PTPN13 mRNA levels in 10 normal liver tissue samples, 8 HBV-HCC tissue samples and 20 HBV + HCC tissue samples normalized to GAPDH expression. B Left: PTPN13 expression was determined by IHC staining. Representative images of a subset of the tumor specimens are shown. The lower panel shows magnified views (4×), shown in boxes in the upper panel. Right: IHC scores for PTPN13 in the two groups are summarized. C The expression levels of PTPN13 were analyzed according to patient HBV positivity. Data are shown after a log2 transformation. D Kaplan–Meier survival curve analysis in HCC patients stratified by the combination of the HBV status and PTPN13 expression is shown. E The effects of transient HBx overexpression in Huh7 and HepG2 cells, HepG2.2.15 cells (integration of the HBV genome) and HBx knockdown with siRNA in PLC/PRF/5 cells (derived from HBV-infected liver) on the mRNA and protein expression levels of PTPN13. F DNA synthesis in stable HBx-overexpressing cells with transient PTPN13 overexpression and stable HBV-overexpressing HepG2.2.15 cells with transient PTPN13 overexpression, as measured by an EdU assay. The data represent the mean ± standard deviation (SD) of three independent experiments (*P < 0.05, **P < 0.01, and ***P < 0.001 compared with the respective control).