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. 2020 Nov 11;52(1):87–99. doi: 10.1007/s10735-020-09926-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Whole transcriptome analysis of differentiation of hPSCs to CMs. a Correlation heatmap for bulk time-course RNA-seq samples. b Principal components analysis (PCA) of RNA-seq samples for hiPSCs at differentiated day 0, 2, 3, 5, 15, 21, and 35. c Expression level for stage-specific genes during hiPSC-derived cardiac differentiation. pluripotency genes (DNMT3B, NANOG, and POU5F1), mesendoderm genes (EOMES, MESP1, and MIXL1), transcription factors (ISL1, HAND1, and GATA4), calcium handling gene (ATP2A2), and sarcomere genes (MYH6, MYH7, MYL7, MYL2, and TNNI1). d Heatmap comparing expression of cardiac genes in hPSC-derived CMs from day 15, 21, and 35 samples relative to samples (d14, d30, and d90 samples) from B27-supplemented medium (J. Churko et al., 2018), as well as human fetal and adult heart samples (ENCODE)