Table 2.

Parameter values and their ranges and distributions for the hypothetical case study

Parameter	Base case	Type of range	Range	Distribution	Distribution parameters
Survival parameters					Mean	SD
PFS λ comparator	0.25	95% CI	0.100–0.400	Normal	0.25	0.077
PFS λ intervention	0.05	95% CI	0.017–0.083	Normal	0.05	0.017
OS λ comparator	0.03	95% CI	0.021–0.039	Normal	0.03	0.005
OS HR intervention	1.00	95% CI	0.800–1.250	Lognormal	1.00	0.114
Utility parameters					Alpha	Beta
Utility PFS	0.80	95% CI	0.610–0.930	Beta	17.80	4.70
Utility PPS	0.50	95% CI	0.200–0.800	Beta	4.54	4.54
Cost parameters					Mean	SD
Costs PFS (€)	1200	± 50%	600–1800	Normal	1200	306
Costs PPS (€)	2000	± 25%	1500–2500	Normal	2000	255
Costs death (€)	1500	± 25%	1125–1875	Normal	1500	191
Costs intervention (€)	750	± 25%	563–938	Uniform	N/A	N/A
Discount rates
Discount rate costs	3.5%	Fixed range	0.015–0.055	Uniform	N/A	N/A
Discount rate benefits	3.5%	Fixed range	0.015–0.055	Uniform	N/A	N/A

CI confidence interval, HR hazard ratio, OS overall survival, PFS progression-free survival, PPS post-progression survival, N/A not applicable, SD standard deviation