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. 2021 Jan 4;12(1):35. doi: 10.1038/s41419-020-03330-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Phase-contrast images showing progression of fungal elements on hPEOs infected by T. rubrum conidia over time. B Periodic-Acid Schiff (PAS) staining of infected hPEOs without antibiotic treatment. C The TEM of infected hPEOs after 24 h. D PAS staining of infected hPEOs with antibiotic treatment from 24 h. E, F The TEM of infected (E), antibiotic-treated (F) hPEOs after 36 h. G Volcano plot showing differential expression of host genes between T. rubrum-infected and control hPEOs at 24 h. Each dot represents a gene. The red and blue dots represent differentially expressed genes with P < 0.05. H GO analyses of upregulated genes in T. rubrum group versus control group. I Heatmap showing the expression of induced innate immunity-related genes. J qRT–PCR analysis of the expression of genes belonging to IL-1 receptor binding in T. rubrum group and the controls. K Immunohistochemical staining for IL-1RN in hPEOs of T. rubrum group and the controls. L Secretion lever of IL-1RN in culture supernatant of T. rubrum group and the control group at 24 h. AmB: amphotericin B. Scale bar: 100 μm (A), 50 μm (B, D, and K), 0.5 μm (C), 2 μm (E, F).