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. 2021 Jan 5;12(1):44. doi: 10.1038/s41419-020-03322-y

Fig. 8. Snai1-induced EMT orchestrates p53–p21 axis via NF-κB pathway.

Fig. 8

UUO mice were injected with Bay11-7082, the NF-κB inhibitor after the administration of either Snai1 or p53 plasmid. A Immunohistochemistry staining of α-SMA, p53, p21, and Ki-67 in different groups and B their quantifications. Scale bar = 100 μm for α-SMA and scale bar = 50 μm for p53, p21, and Ki-67. C Cell cycle distribution of TECs isolated from obstructed kidneys in different groups. D Relative mRNA expression of IL-1β, IL-6, and TNF-α in kidneys from different groups. E Immunohistochemistry staining of F4/80 in different groups and F their quantifications. Scale bar = 100 μm. *P < 0.05; **P < 0.01; ***P < 0.001 compared with UUO + Snai1 plasmid group. #P < 0.05; ##P < 0.01; ###P < 0.001 compared with UUO + p53 plasmid group.