Table 4.

The list of adverse events, during and up to one week after the infusion

Participants number	Medication	Adverse events during and in one hour after the infusion	Severity	Pre-infusion blood pressure	Maximum blood pressure during and up to one-hour post infusion	Adverse events up to one week after the infusion (assessed on day 7 post infusion)	Severity
1	Ketamine	Nausea	Moderate	154/73	173/82	Stiffness	Mild
		Vomiting	Mild
		Euphoria	Moderate
		Dizziness	Mild
		Altered smell sensation	Mild
2	Midazolam	Sleepiness	Mild	109/61	125/72	None
		Slurred speech	Mild
		Chills	Mild
3	Midazolam	Sleepiness	Mild	127/74	155/81	None
		Wooziness	Mild
		Slurred speech	Mild
		Sedation	Mild
4	Ketamine	Relaxation	Mild	123/62	141/81	Impaired Concentration	Mild
		Euphoria	Mild			Feverish	Mild
		Tingling in hands/feet	Mild
		Impaired concentration	Mild
		Increased appetite	Mild
5	Ketamine	Lightheadedness	Mild	123/86	168/104	None
		Sleepiness	Mild
		Lip numbness	Mild
		Generalized numbness	Mild
6	Ketamine	Lightheadedness	Mild	126/84	149/92	Dizziness	Mild
		Dizziness	Mild			Tinnitus	Mild
		Impaired concentration	Mild
		Slowed thinking	Mild
		Euphoria	Mild
		Hand numbness	Mild
		Dry lips	Mild
		Speech disturbance	Mild
7	Ketamine	Drowsiness	Mild	127/82	135/76	Insomnia	Moderate
		Visual disturbance	Mild
		Dizziness	Mild
		Increased salivation	Mild
		Numbness	Mild
		Headache	Mild
8	Ketamine	Feeling relaxed Euphoria	Mild Mild	131/80	168/79	None
		Sensory abnormality	Mild
		Visual disturbance	Mild
		Leg numbness	Mild
		Loss of inhibition	Mild
9	Midazolam	Sleepiness	Mild	111/73	105/66	None
		Yawning	Mild
10	Ketamine	Lightheadedness	Moderate	141/79	155/77	None
		Euphoria	Mild
		Facial numbness	Mild
		Hot flushes	Mild
11	Midazolam	None		144/86	130/88	None
12	Ketamine	Lightheadedness	Mild	118/70	125/73	None
		Leg numbness	Mild
		Facial numbness	Mild
		Flushing	Mild
		Foggy feeling in head	Mild
		Impaired concentration	Mild
13	Ketamine	Dizziness	Mild	126/84	171/95	Fever	Mild
		Euphoria	Mild
		Drowsiness	Mild
		Impaired concentration	Mild
		Word finding difficulty	Mild
		Finger numbness	Mild
14	Midazolam	Drowsiness	Mild	118/67	142/71	Drowsiness	Mild
15	Ketamine	Dizziness	Mild	141/87	157/85	Mental	Mild
		Lightheadedness	Mild			impairment Depression	Moderate
		Dry mouth	Mild			Fatigue	Mild
		Flushing	Mild
		Restlessness	Mild
		Mental impairment	Mild
		Numbness	Mild
		Tremulousness	Mild
		Sensation of warmth	Mild
		Euphoria	Mild
		Impaired concentration	Mild
		Altered taste	Mild
16	Ketamine	Elevated mood	Mild	145/82	178/86	None
		Lightheadedness	Mild
		Dizziness	Mild
		Impaired concentration	Mild
		Euphoria	Mild
		Tinnitus	Mild
17	Ketamine	Giddiness	Mild	109/67	143/83	None
		Euphoria	Mild
		Transient alteration of awareness	Mild
		Face numbness	Mild
		Pain relief	Mild
		Tinnitus	Mild
		Impaired concentration	Mild
		Lightheadedness	Mild
18	Midazolam	Sleepiness	Mild	127/76	122/69	None