TABLE 1.
LONG ACTING DRUGS IN DEVELOPMENT FOR HIV PREVENTION AND TREATMENT BY INFUSION, INJECTION OR IMPLANT
ARV Class | Agent | Formulation | Development Stage |
---|---|---|---|
NRTI | Islatravir (MK-8591) | Implant | Phase I |
TAF | Implant | Phase I/II (Px) | |
GS-9131 | Implant | Preclinical | |
NNRTI | Rilpivirine | Injectable | Phase III/NDA |
Elsulfavirine | Injectable | Preclinical | |
PI | Atazanavir | Injectable | Preclinical |
Ritonavir | Injectable | Preclinical | |
INSTI | Cabotegravir | Injectable | Phase III/NDA, Phase II/III (Px) |
Dolutegravir | Implant | Preclinical (Px) | |
Raltegravir | Injectable | Preclinical | |
Entry Inhibitors | Ibalizumab | Intravenous | FDA Approved (Tx) |
Leronlimab (PRO 140) | Intravenous and Injectable | Phase III | |
Albuvirtide | Intravenous and injectable | Approved in China | |
bNAbs (e.g., VRC01, VRC07) | Intravenous | Phase I/II/III | |
Combinectin | Intravenous | Phase I | |
Capsid Inhibitors | GS-6207 | Injectable | Phase II |
ARV = antiretroviral; Px = prevention; Tx = treatment