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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Nature. 2020 Nov 4;589(7840):88–95. doi: 10.1038/s41586-020-2879-3

Figure 5: Dorsal and ventral visual circuits are partitioned by differential Wnt signaling.

Figure 5:

a, Pattern of Wnt4-Gal4 and Tm9-LexA co-expression (white) at P50 in the ventral and dorsal part of the same optic lobe (n=8 brains). Red dashed line: location of photoreceptors. b, Wnt4-Gal4 expression pattern with anti-Chaoptin staining to mark photoreceptors in a P30 retina (n=6 eye discs). Dashed rectangle: inset. Dashed line within inset: equator of the retina. c, tSNE of the indicated clusters throughout development, with Wnt4 and Wnt10 log-normalized non-integrated expression levels. d, 5-HT1A differential expression between either Wnt4+/Wnt10- and Wnt4-/Wnt10+ Tm4 cells, or Tm9v and Tm9d cells (Methods). ***: adjusted p-value < 0.001 (P70 Tm9: 6×10−9, Adult Tm9: 3×10−18, P50 Tm4: 1×10−9, P70 Tm4: 2×10−7, Adult Tm4: 1×10−34), ns: not significant, two-sided Wilcoxon Rank Sum test. Scale bars = 30 μm.