Figure 1.

Events that drive cellular senescence and events driven by senescence. Senescence can be driven by different types of cellular stress, including genotoxicity, telomere shortening, epigenetic dysregulation, oncogene activation, mitochondrial dysfunction, and metabolic and oxidative stress. This leads to signaling events that result in senescence. Senescent cells have a robust SASP, which can reinforce and spread senescence, locally and systemically, inhibiting stem cell function and disrupting tissue homeostasis while increasing sterile inflammation, termed inflammaging. Figure adapted, with permission, from the original figure by Dr. Rajesh Vyas. Abbreviation: SASP, senescence-associated secretory phenotype.