Table 2.
Novel index variants identified for association with body mass index in meta-analysis (P<5e-8) of adult survivors of childhood acute lymphoblastic leukemia by cranial radiation therapy.
| CCSS Diagnosed 1970-1986 |
SJLIFE | CCSS Diagnosed 1987-1999 |
Meta-Analysis | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment group |
Locus | SNP | Risk allele |
MAF | n | beta | se | p | n | beta | se | p | n | beta | se | p | beta | se | p |
| CRT | LINC00856 | rs575792008 | A | 0.006 | 962 | 7.5 | 1.4 | 9.4E-08 | 151 | 10.8 | 6.8 | 0.12 | 109 | NA | NA | NA | 7.7 | 1.4 | 2.3E-08 |
| no CRT | EMR1 intron | rs62123082 | G | 0.011 | 496 | 7.6 | 1.3 | 5.8E-09 | 247 | −4.7 | 4.3 | 0.28 | 280 | 8.5 | 2.5 | 8.7E-04 | 7.0 | 1.1 | 2.8E-10 |
CRT, cranial radiation therapy; MAF, minor allele frequency; NA, variant not present in cohort; SNP, single nucleotide polymorphism. The units for effect estimates are change in body mass index (kg/m2) per minor allele.