Figure 7.
Effects of NKG2Dbp CAR-T Cells in a Mouse Model of SKOV3 Human Ovarian Cancer Cells
(A) The experimental outline for the investigation of anti-tumor effects of NKG2Dbp CAR-T cells in an i.p. injection SKOV3 xenograft model. Three groups of mice (5 mice per group) received an i.p. injection of 1 × 107 SKOV3 cells (day 0) followed by an i.p. injection of PBS, control CAR-T cells, or NKG2Dbp CAR-T cells on day 7 and day 14 (1 × 107 cells per injection per mouse). Growth of SKOV3 was monitored by bioluminescent imaging on the indicated days. (B) Tumor burden images by bioluminescent imaging from day 7 to day 42. (C) Kaplan-Meier analysis of survival of the in vivo experiment. Statistical analysis of survival between groups was performed using the log-rank test.