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. Author manuscript; available in PMC: 2021 Jan 25.
Published in final edited form as: Int J Pharm. 2020 Nov 26;593:120120. doi: 10.1016/j.ijpharm.2020.120120

Fig. 1. Intestinal permeability of macromolecules is a function of molecular size, mouse age, and tissue type.

Fig. 1.

In these experiments, FITC-dextrans between 4 and 150 kDa were introduced into non-evert stomach or gut sacs from 2 week old (black), 4 week old (white) and 12 week old (blue) mice. Apparent permeability (Papp) in the intestine decreased with age, the size of the dextran, and the tissue’s distance from the stomach. Papp values represent the mean ± SEM (n = 5). One-way ANOVA with Dunnett’s multiple comparison test; * P < 0.05, ** P < 0.01, *** P < 0.001, compared to respective size marker in 12 week old mice.