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. Author manuscript; available in PMC: 2021 Jan 25.
Published in final edited form as: Int J Pharm. 2020 Nov 26;593:120120. doi: 10.1016/j.ijpharm.2020.120120

Fig. 3. – Infant and adult intestinal mouse tissue differ in morphology and tight junction localization.

Fig. 3. –

In each representative immunofluorescence image, nuclei are stained with DAPI (blue) and the protein of interest appears in green. Cytoskeleton (F-actin) staining showed taller, more mature villi in adult tissue. While the barrier-forming Claudin 3 (CLDN3) appears throughout adult villi, it is localized exclusively to the crypts in infant tissue. Cross sections of villi show localization of Claudin 2 (CLDN2) localized differently in adult tissue (towards cellular junctions) compared to infant tissue (intracellularly).