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. Author manuscript; available in PMC: 2021 Jan 25.
Published in final edited form as: Int J Pharm. 2020 Nov 26;593:120120. doi: 10.1016/j.ijpharm.2020.120120

Fig. 5. – Oral delivery of insulin lowers blood glucose levels in infant mice but not in adults.

Fig. 5. –

A) Infant (2 week old) and B) adult (12 week old) mice were gavaged with either phosphate buffered saline (PBS) or 5 IU/kg insulin or subcutaneously injected with 1 IU/kg insulin. Blood glucose levels decreased after oral insulin in infant animals only. C) The oral normalized area above the curve (AAC) was significantly larger in infant animals. Blood glucose levels represent the mean ± SEM (n = 6). Two-way ANOVA with Bonferroni’s multiple comparison; * P < 0.05, *** P < 0.001, compared to PBS (top panels). Student’s unpaired t test: *** P < 0.001 compared to adult mice (bottom panel).