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. Author manuscript; available in PMC: 2021 Jan 25.
Published in final edited form as: Int J Pharm. 2020 Nov 26;593:120120. doi: 10.1016/j.ijpharm.2020.120120

Table 1 –

Permeability of FITC-Dextrans decreased as a function of dextran size, mouse age, and intestinal tissue type. Apparent permeability (Papp; × 10−5 cm/s) of FITC-Dextran 4, 10, 70, and 150 kDa (FD). Papp values represent the mean ± SEM (n = 5).

Proximal small intestine Distal small intestine Colon
2 wo 4 wo 12 wo 2 wo 4 wo 12 wo 2 wo 4 wo 12 wo
FD4 6.5 ± 0.9 3.1 ± 0.6 3.6 ± 0.4 4.4 ± 0.5 2.1 ± 0.3 1.6 ± 0.2 1.5 ± 0.3 1.1 ± 0.2 1.1 ± 0.2
FD10 3.8 ± 0.4 2.1 ± 0.3 1.8 ± 0.6 1.9 ± 0.3 1.0 ± 0.2 0.7 ± 0.1 0.5 ± 0.1 0.5 ± 0.1 0.5 ± 0.1
FD70 2.6 ± 0.3 1.2 ± 0.3 1.3 ± 0.2 2.1 ± 0.5 0.6 ± 0.4 0.3 ± 0.1 0.5 ± 0.1 0.3 ± 0.2 0.2 ± 0.1
FD150 0.9 ± 0.3 1.5 ± 0.1 1.1 ± 0.3 0.5 ± 0.2 0.2 ± 0.1 0.2 ± 0.1 0.2 ± 0.1 0.1 ± 0.1 0.2 ± 0.1