Table 1.

Formulation parameters and designed particle composition by mass of the human inhalable vaccine candidates.

Component\Formulation	T	T20Leu	T10Pul	T20Pul	T3Tri	T6Tri
Feedstock Composition (mg/mL)
Leucine	-	10.0	-	-	-	-
Pullulan	-	-	4.5	10.5	-	-
Trileucine	-	-	-	-	1.3	2.6
Trehalose	33.3	33.3	33.3	33.3	33.3	33.3
Tris (buffer)	0.807	0.807	0.807	0.807	0.807	0.807
Squalene	5.73	5.73	5.73	5.73	5.73	5.73
DMPC	1.27	1.27	1.27	1.27	1.27	1.27
GLA	0.0033	0.0033	0.0033	0.0033	0.0033	0.0033
ID93	0.0013	0.0013	0.0013	0.0013	0.0013	0.0013
Total Feed Concentration	41.1	51.1	45.6	51.6	42.4	43.7
Particle Composition (w/w)
Leucine	-	20%	-	-	-	-
Pullulan	-	-	10%	20%	-	-
Trileucine	-	-	-	-	3%	6%
Trehalose	81%	65%	73%	65%	78%	76%
Tris (buffer)	2%	2%	2%	2%	2%	2%
Squalene	14%	11%	12%	11%	14%	13%
DMPC	3%	2%	3%	2%	3%	3%
GLA	0.01%	0.01%	0.01%	0.01%	0.01%	0.01%
ID93	0.003%	0.003%	0.003%	0.003%	0.003%	0.003%