Figure 1.

LINC00618 Is Induced by VCR and Highly Downregulated in Human Acute Myeloid Leukemia (AML)

(A) The relative proliferation levels of K562, HL60, and MV4-11 cells checked by MTS assays with the indicated doses of VCR treatment. DMSO served as control. (B) The expression profiling of screened lncRNAs in AML from TCGA-LAML. (C) VCR induced the expression of LINC00618 for 0 h (0 H), 24 h (24 H), and 48 h (48 H) in MV4-11 cells and K562 cells. (D) LINC00618 expression is presented as box plot diagrams in AML patient samples. (E) RNA FISH analysis of LINC00618 localization in MV4-11 cells, K562 cells, and HL60 cells using Cy3-labeled probes. All scale bars, 25 μm long. Data are shown as the mean ± SEM; n ≥ 3 independent experiments, two-tailed Student’s t test: ns, nonsignificant (p > 0.05), ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.