Skip to main content
. 2021 Jan 5;11:19. doi: 10.1038/s41398-020-01138-0

Fig. 1. Schematic representation of the TCF4 genomic locus.

Fig. 1

The genomic locus is located on chromosome 18 (top line; exon sizes and distances between exons shown to scale), coding exons (middle lines; exon sizes, but not distances, shown to scale), and TCF4 protein domain structure (bottom line; domain sizes not to scale). The last exon on the right, displayed in gray, is non-coding. Only transcript variants coding for isoforms TCF4-B and TCF4-A are shown, which are transcribed from alternative promoters starting at exons 3 and 10, respectively. AD activation domain, NLS nuclear localization signal, NES nuclear export signal, bHLH basic helix–loop–helix DNA-binding domain, CE conserved element, Rep repression domain. In the bottom line, the protein motifs inside the bHLH domain are shown in detail in the enlarged inset. Based on refs. 22,61.