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. 2021 Jan 4;11:8. doi: 10.1038/s41398-020-01127-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Study-specific direction signed log(p-values) for the top 12 genes separated by sex and region. Cell colours range from blue to red, which represents lower and higher expression in cases compared to controls, respectively. Colour intensity represents the degree of differential expression. Missing values are marked in gray. b Corrected meta p-values for the same genes across the 8 across-study meta-analyses. Cell colours range from low (yellow) to high (purple) corrected p-values in each meta-analysis. ACC anterior cingulate cortex (two studies), DLPFC dorsal lateral prefrontal cortex, nAcc nucleus accumbens, Ins anterior insula, Sub subiculum, AMY amygdala, SI sex interaction.