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. 2021 Jan 4;12(1):17. doi: 10.1038/s41419-020-03327-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — р53 mediates expression of the indicated miRs (denoted with blue color) that in turn target Zeb1/2 EMT-TFs (denoted as burgundy-colored boxes). Long non-coding RNAs (lncRNAs) denoted with pink-color act as competing endogenous RNAs (ceRNAs) to counteract the effect of miRs. Interactions between all of these players form simple links and feedback loops (indicated with arrows and bars). Positive influence is denoted by blue arrows and negative is denoted by red bars.