Table 3.

miRNAs targeting Twist1.

miRNA	Targets	Cancer subtype	Expression changes	Effect	References	p53 regulation
miR-129-5p	Twist1	HER2+	­	High level is associated with sensitivity of BC cells to trastuzumab	145	Has potential p53 response elements in promoter
		N/S	↓	Low level is associated with breast cancer diagnosis; Suppresses the proliferation of BC cells	146
		TN	­	Overexpression sensitized MDA-MB-231 cells to irradiation	147
		LA	–	Knockdown of miR-129-5p reduced radiosensitivity of MCF-7 cells
miR-526b	Twist1	N/S	­	Associated with reduced patients survival and higher tumor grade	148
miR-33b	Twist1	N/S	↓	Downregulated in BC, its expression negatively correlates with lymph node metastasis and tumor stage	66	May repress p53 in hematopoetic stem cells

BC breast cancer, LA luminal A subtype, TN triple-negative (basal-like) subtype, HER2+ HER2-positive subtype, N/S subtype is not specified.