Skip to main content
. 2021 Jan 4;12(1):33. doi: 10.1038/s41419-020-03306-y

Fig. 6. The role of miR-153-5p on tumor progression is mediated via the downregulation of AGO1.

Fig. 6

A The expression level of mRNA and protein of AGO1 in 786-O and TK10 after transfection with siRNA of AGO1. B The proliferation rate of ccRCC after AGO1 knockdown. C Effect of AGO1 knockdown on migration and invasion. The proliferation (D) and metastasis (E) of ccRCC after co-transfection with miR-153-5p inhibitor or NC inhibitor with either AGO1 siRNA or NC. F The alterations of the PI3K/Akt pathway after co-transfection with miR-153-5p inhibitor or NC inhibitor with either AGO1 siRNA or NC. All experiments were conducted at least three independent times and all the values were presented as mean ± SEM. *P < 0.05, **P < 0.01 (B vs. NC; D vs. anti-miR-153 + NC); #P < 0.05, ##P < 0.01; B vs. si-AGO1-932; D vs. anti-miR-153-5p + si-AGO1).