Table 1.
Post-mortem studies exploring 5-HT1A receptors in schizophrenia.
| Reference | Schizophrenia group | Control group | Radiotracer | Region of interest | Main result |
|---|---|---|---|---|---|
| 36 | n = 13; mean age 55 +/−16 yrs; 8 M/5 F; suicide 2/13; antipsychotics 12/13 | n = 15; mean age 59 + /−15 yrs; 9 M/6 F; suicide 2/15 | [3H]-8-OH-DPAT | DLPFC (BA 46) | Increase (23%) |
| ACC (BA 24) | NS | ||||
| STG; striatum, cortex; hippocampus | NS | ||||
| 37 | n = 9; mean age 53 +/−15 yrs; 4 M/5 F; suicide 1/9; antipsychotics 8/9 | n = 9; mean age 58 +/−17 yrs; 5 M/4 F; no suicide | [3H]-WAY-100635 | DLPFC (BA 46) | Increase (17%) |
| ACC (BA 24) | NS | ||||
| 43 | n = 10; mean age 60 +/−3.7 yrs; 7 M/3 F; no suicide; antipsychotics 8/10 | n = 10; mean age 60 +/−3.8 yrs; 7 M/3 F; no suicide | [3H]-8-OH-DPAT | DLPFC (BA 8, 9, 10) | NS |
| 42 | n = 8; 5 M/3 F; no suicide; antipsychotics 8/8 |
Healthy controls: n = 8; 5 M/3 F; no suicide Bipolar I disorder: n = 8; 4 M/4 F; no suicide; antipsychotics 5/8. |
[3H]-8-OH-DPAT | Frontal cortex (BA 9,10, 40, 46) | NS |
| 40 | n = 10; mean age 75.4 +/−1.5 yrs; 6 M/4 F; antipsychotics 4/10; no suicide | n = 13; mean age 63.3 +/−3.3 yrs; 7 M/4 F; no suicide | [3H]-8-OH-DPAT | ACC (BA 24) | Increase |
| PFC (BA 6,9a and 44) | Increase | ||||
| Motor cortex; sensori-motor cortex; infra-parietal cortex; PCC | NS | ||||
| 38 | n = 10; mean age 67.3 +/−3.8 yrs; 6 M/4 F; antipsychotics 5/10 | n = 11; mean age 63.6 +/−4 yrs; 4 M/7 F | [3H]-8-OH-DPAT | PFC (BA 10) | Increase (40%) |
| Temporal cortex (BA 22) | Increase (60%) | ||||
| Parietal cortex; motor cortex; occipital cortex; cingulum; amygdala; hippocampus | NS | ||||
| 44 | n = 10; mean age 49 +/−18 yrs; 7 M/3 F; suicide 4/10; antipsychotics 7/10 |
Control group: n = 8; mean age 68 +/−15 yrs; 4 M/4 F; no suicide Suicide/affective illness group: n = 8; mean age 38 +/−13 yrs; 5 M/3 F; medication 4/10 |
[3H]-8-OH-DPAT | Motor cortex (BA 4) | Increase |
| ACC (BA 24) | Increase | ||||
| PCC (BA 23) | Increase | ||||
| Hippocampus | Increase | ||||
| Temporal cortex; striatum; frontal (BA9) | NS | ||||
| 45 | n = 20; mean age 47.35 +/−3.7 yrs; 11 M/9 F; suicide 5/20; antipsychotics 20/20 | n = 20; mean age 46.2 +/−3.4 yrs; 13 M/7 F; no suicide | [3H]-8-OH-DPAT | Hippocampus | NS |
| 39 | n = 12; mean age 59 +/−6 yrs; 9 M/3 F; suicide 4/10; antipsychotics 10/12 | n = 18; mean age 63 +/−2 yrs; 13 M/5 F; no suicide | [3H]-8-OH-DPAT | Medial orbital gyrus | Increase |
| Straight gyrus | Increase | ||||
| Olfactory sulcus | Increase | ||||
| 46 | n = 19; mean age 54.3/−1.4 yrs; 14 M/5 F; antipsychotics 19/19 | n = 16; mean age 71.5 +/−3.9 yrs; 10 M/6 F | [3H]-8-OH-DPAT | Cerebellar vermis lobules | Increase |
| 41 | n = 12; mean age 37.8 + /−2.9 yrs; 7 M/5 F; suicide 5/12; antipsychotics 10/12 | n = 12; mean age 37.1 +/−3.4 yrs; 10 M/1 F; no suicide; medication 3/10 | [3H]-8-OH-DPAT | PFC (BA10) | Increase (79%) |
ACC anterior cingulate cortex, BA Brodman’s area, DLPFC dorsolateral prefrontal cortex, F females, M men, NS non-significant, PFC prefrontal cortex, PCC posterior cingulate cortex, STG superior temporal gyrus, yrs years.