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. 2021 Jan 5;12(1):1. doi: 10.1038/s41419-020-03229-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The location of p53BER2 in RCC cell lines with confocal image, scale bar, 20 μm. B Heatmap representation of differentially expressed genes identified by RNA-Seq between P53BER-KD group and control group. C The Go terms enriched analysis of different biological processes in p53-KD and NC RCC line by RNA-sequencing. D Overlap of the differential genes of the two cell lines and the differential genes related to the cell-cycle pathway. E The BRCA2 expression level of different RCC cell lines infected p53BER2-KD virus and vectors after nutlin-3 treatment(30uM). F HR efficiency of ACHN and OSRC-2 after p53BER2 knockdown. G Western blot of yH2AX in p53BER2-KD and control cells after nutlin-3 treatments (30 μM). H Western blot of OSRC-2 and ACHN cells after transfected with BRCA2. I The proportion of cell cycle of ACHN-KD transfected BRCA2 after nutlin-3 treatment (30 μM). EV empty vector, KD p53BER2 knockdown, OE overexpression. Results are shown as mean ± SD. ***P < 0.001 compared with control. **P < 0.01 compared with control. *P < 0.05 compared with control.