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. 2021 Jan 5;12(1):1. doi: 10.1038/s41419-020-03229-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Image of 18 xenografts formed by ACHN-KD1, KD2, and Control. B Growth curves of mice subcutaneous xenografts derived from ACHN-KD1, KD2, and Control cells (left panel). Tumor weights were statistically analyzed (right panel). C Image of 15 xenografts formed by OSRC-2-KD1, KD2, and Control with nutlin-3 treatment. D Growth curves of mice subcutaneous xenografts derived from OSRC-2-KD1, KD2, and Control cells with nutlin-3 treatment (left panel). Tumor weights were statistically analyzed (right panel). E Image of 15 xenografts formed by ACHN-KD1, KD2, and Control with nutlin-3 treatment. F Growth curves of mice subcutaneous xenografts derived from ACHN-KD1, KD2, and Control cells with nutlin-3 treatment (left panel). Tumor weights were statistical analyzed (right panel). G BRCA2 expression in mice subcutaneous xenograft. Results are shown as mean ± SD. ***P < 0.001 compared with control. **P < 0.01 compared with control. *P < 0.05 compared with control. H Schematic model of P53BER2-dependent regulation of P53 activity in p53-MUT or TP53-WT condition.