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. 2021 Jan 7;12(1):42. doi: 10.1038/s41419-020-03299-8

Fig. 8. Schematic diagram of the mechanism by which TRIB2 and PCBP2 modulate proteasome function to reduce Ub and protect cells against OS via GPX4.

Fig. 8

Briefly, TRIB2 cooperates and stimulates PCBP2 to reduce the global K48-Ub level. PSMB5 is the target of these proteins, and its activity is directly promoted by PCBP2. The levels of PCBP2 and GPX4 can be upregulated via suppression of their ubiquitination. Moreover, GPX4 functions as one of the terminal effectors of TRIB2 and PCBP2 to protect liver cancer cells from oxidative damage.